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R., Sanches, P
In the context of cancer, NRF2 has traditionally been considered a tumor suppressor because its cytoprotective functions are considered the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress

102 In addition to GBA , an association between mutations in the sphingomyelin phosphodiesterase SMPD1 or in ASAH1 , a lysosomal ceramidase, and PD were identified recently

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

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NP, based on systems biology, studies drug-target-disease networks, revealing the potential for multitargeted therapies
