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Tesofensine at doses of 0.25 mg, 0.5 mg, and 1.0 mg led to weight loss of 4.5%, 9.2%, and 10.6% respectively, which was significantly higher than the weight loss achieved with diet and placebo

What the FDA announced this week is not a major policy shift

We therefore, recommend to stop cuprizone after 5 weeks

Clinically, these disruptions manifest as visceral hypersensitivity, dysmotility, bloating, and food intolerances, aligning with the pathological framework of intestinal hyperpermeability syndrome (leaky gut), which may progress to hemorrhagic diarrhea in severe colitis (60)

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