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People who take certain medications may also be at risk of vitamin B12 deficiency, including, but not limited to, estrogen, H2 receptor antagonists, PPIs (Proton Pump Inhibitors), Chloramphenicol, and Metformin

Closed-head impact model of engineered rotational acceleration (CHIMERA) model has offered versatility in terms of controlled severity of injury, ranging from 0.7 joules simulating a mild TBI model to 2.5 joules simulating a more severe injury types, based on robust acute neurological deficits, enhanced plasma total tau and neurofilament-light levels, increased pro-inflammatory markers, microgliosis and BBB compromise (Vonder Haar et al., 2019)

In the future, it is necessary to establish animal models

Third, the translation rate

Medical professionals carefully monitor these effects to ensure patient safety throughout the treatment process

Cureus, 14(1), e21476