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The dose-dependent activation of the FAK-paxillin pathway has been documented in multiple studies

Phenytoin concentrations in the range 1020mg/L are associated with seizure control but, because status epilepticus is a life-threatening condition, the target is usually at least 20mg/L

J Biol Chem (2010) 285(42):3214150

384,385 Additionally, GWAS has identified several novel genetic loci associated with DPN, underscoring the complex genetic architecture underlying this condition