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Copper accumulation is theoretically possible with very high doses over extended periods
Di Renzo MF, Olivero M, Martone T, Maffe A, Maggiora P, Stefani AD, et al

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A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome
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