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Prohibited medications included antipsychotics, psychostimulants, antidepressants, anxiolytics, mood stabilizers, neuroleptics, investigational products in the month leading up to screening, and supplements taken for ASD symptom improvement in the two weeks leading up to screening

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Similar content being viewed by others Introduction Mitochondrial diseases (MDs) are a heterogenous group of inborn metabolic diseases caused by defects in the genes encoding mitochondrial proteins that are required for ATP production from oxidation of substrates via the tricarboxylic acid cycle and the oxidative phosphorylation (OXPHOS)

The BH3-only protein is considered a sensor of the mitochondrial apoptosis pathway, and it is the upstream component of the Bcl-2 family to regulate mitochondrial apoptosis [83]

However, the response may depend on the underlying cause of the short stature and the presence of functional GH pathways

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