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Consistently, a complementary strategy showed that in aged mice, where IGF-I levels are decreased, cardiac overexpression of IGF-I significantly improved cardiomyocyte contractile function[283], attenuating oxidative stress-mediated protein damage, normalizing Ca 2+ homeostasis, reversing age-related alterations in the expression of pro-apoptotic proteins, and decreasing the apoptosis rate[284]

Nat Cell Biol 22(10):12761285 Ruan X et al (2024) Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis

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The pre-injection assessment is bundled into the injection payment