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48 While stress is a known trigger of inflammatory signaling, inflammatory cytokines in turn activate the stress response, and a heightened inflammatory response to stressful circumstances has been noted in both individuals with depression and those at high risk of depression

To determine whether HDAC9 is necessary for synaptic plasticity in the hippocampus, extracellular recordings of field excitatory postsynaptic potentials (fEPSPs) were conducted in the CA1 area of hippocampal slices from HDAC9 / mice and their WT littermate controls, specifically targeting synapses in the stratum radiatum, where Schaffer collateral inputs from CA3 neurons terminate on the apical dendrites of CA1 pyramidal neurons (Fig

Although neurons lack pyruvate carboxylase, they contribute to de novo glutamate synthesis by the pyruvate carboxylation to malate through the malic enzyme, which is found in the cytosol and mitochondria (McKenna et al., 1995