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Description
In turn, PER and CRY bind to CLOCK and BMAL1 to inhibit their own expression

10.3390/ijerph17186686 31

doi: 10.1016/S1470-2045(09)70025-7 2 van LindeMEBrahmCGde Witt HamerPCReijneveldJCBruynzeelAMEVandertopWPet al
Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J

A literature review

This behavior is very common for some of the penicillins that are extensively bound to plasma protein, but their elimination half-lives are short, which could be attributed to rapid elimination by active secretion
