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Given the tight coupling between the immunosuppressive TME and its unique metabolic reprogramming (e.g., high glucose consumption, elevated lactate levels, low pH, and hypoxia), interventions targeting metabolism (such as inhibiting lactate production or transport) can not only directly decrease the survival advantages of tumor cells but also significantly increase the function and tumor-infiltrating capacity of effector immune cells, such as CD8 + T cells

The anti-inflammatory effects of CoQ10 are thought to protect against cardiovascular disease.[ref] Statins are the most prescribed class of drug in the U.S., and statins act to block the pathway involved in both LDL and CoQ10 production .[ref] A meta-analysis that involved data from 12 RCTs found that statins clearly reduce circulating CoQ10 levels

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