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4b), and more importantly, because it was predicted by TargetScan to target the IGF-1 gene 41 (Supplementary Fig

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During injury states, the peptide helps regulate the inflammatory response, reducing the overproduction of pro-inflammatory cytokines that can perpetuate pain and tissue damage

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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]