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Participants in phase 6 only were paid 30 to complete the study

In the UK, hydroxocobalamin 1 mg intramuscular injection is used: Without neurological involvement : 1 mg three times weekly for two weeks, then maintenance of 1 mg every two to three months With neurological involvement : 1 mg on alternate days until no further improvement in symptoms, then maintenance of 1 mg every two months Lifelong maintenance is required for pernicious anaemia or other irreversible causes of deficiency Oral B12 supplementation may be appropriate for diet-related deficiency in patients without neurological symptoms and with adequate absorption capacity

PMID 6653901)

Wirtz PW, Smallegange TM, Wintzen AR, Verschuuren JJ

doi: 10.1139/apnm-2018-0039 101 BartlettDBSlentzCAWillisLHHoseltonAHuebnerJLKrausVBet al

MAPT haplotype and mild cognitive impairment