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However, the oral administration of -lipoic acid results in a limited pharmacokinetic profile, characterised by a short half-life, reaching the maximum plasma concentration in approximately 30 min, and reduced bioavailability (about 30%) [54,55,56,57,58]

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The mechanism involved is likely related to its antioxidant properties, and high serum concentrations appear to be associated with a lower risk of aggressive disease, though evidence is still limited (373)

Maintenance phase (weeks 512): 22.5 mg SC, once weekly

it can reach high intracellular and plasma concentrations, and it has been detected in breast tissues after a single oral administration [62,63]