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These findings suggest that targeting stress response pathways, particularly GCN2-mediated ISR and UPR activation could represent a new therapeutic strategy for OS
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Both cysteines belong to the interface region 58 hTrx1 to 74 hTrx1 and are located on the same helix separated by two turns
Under hypoxic conditions, the process of reductive carboxylation takes precedence over oxidative carboxylation, which is primarily facilitated by the activity of HIF-1 [58]
Methods 149 , 5968 (2018)
