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In a recent prospective, multinational, observational study from Hong Kong, Philippines, South Korea, and Taiwan, 197 moderate-to-severe COPD patients were followed over 1-year and underwent sputum examination by culture and polymerase chain reaction (PCR) to examine presence of pathogenic bacteria and viruses during both stable states as well as during exacerbations

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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Ulker P., Sati L., Celik-Ozenci C., Meiselman H.J., Baskurt O.K