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Description
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As a pleiotropic cytokine that orchestrates a broad range of physiological and pathological processes, including immune homeostasis, extracellular matrix remodeling, epithelial barrier integrity, and fibrosis, TGF-1 assumes a central mechanistic role by perpetuating immune dysregulation and promoting fibrotic and epithelial injury across multiple organ systems

Pharmacokinetics and bio-distribution in vivo Encouraged by the effective PSC re-education and ECM inhibition by Au@PP/RA/siHSP47 in vitro, we further examined the effects of the nano-strategy in a Panc-1/PSC, co-inoculated, subcutaneous xenograft mouse model
It is important for maintaining healthy nerve cells, producing DNA, and keeping red blood cells healthy

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