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Decades of follow-up work turned it into one of the most studied peptides in cosmetic science

The earliest effects usually involve anti-inflammatory action

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The 677T allele (Ala222Val) was positively correlated with testosterone concentrations, FAI (free androgen index), and FEI (free oestrogen index)
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A 2023 double-blind clinical study confirmed measurable collagen upregulation at the tissue level in human skin biopsies following 12 weeks of GHK-Cu topical application
