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However, the lack of reagents like antibodies, inhibitors, and cellspecific deletions for many SLE members remains a major hurdle [275]

Lactate dehydrogenase A (LDHA), crucial in lactate metabolism by regulating the lactate/pyruvate interconversion, is essential both for lactate-driven TCA cycling and for histone lactylation (85)

Tumor-associated metabolic stress, characterized by glutathione depletion, iron overload, and reactive oxygen species (ROS), creates an environment permissive to ferroptosis [307]

Crema: Purified water, butylene glycol, beeswax, caprylic/capric triglyceride, niacinamide, cetearyl alcohol, isononyl isononanoate, arachidyl alcohol, 1,2-hexanediol, polyglycerides Reel-3methylglucose distearate, behenyl alcohol, glyceryl stearate, betaine, arachidyl glucoside, allanto , sorbitanolibate, panthenol, hydrogenated lecithin, tocopherol, xanthan gum, glycerin, Glutathione (600 ppm), ethylhexyl glycerin, dipotassium glycyrrhizate, stearic acid, disodium EDTA, bisabolol, sodium hyaluronate, ascorbyl tetraisopalmitate, glucose, balm leaf extract, lady's mantle extract, yarrow extract, speedwell extract, peppermint leaf extract, sulfate primrose extract, polyglyceryl-10 stearate, ceramide NP, sodium ascorbyl phosphate, ceramide NS, cholesterol, phytose Pingosine, Ceramide AP, Ceramide AS,Sodium Hydroxide, Biotin, Acetylhexapeptide-8, Copper Tripeptide-1, Pyridoxine, Oligopeptide-29, Oligopeptide-32, Cyanocobalamine, Palmitoylpentapeptide- 4, Ceramide EP, riboflavin, beta-carotene, thiamine HCL, fragrance.

The details of these gypenosides and their pharmacological properties have been discussed elsewhere (Nguyen et al., 2021)