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however, IgM as well as IgA along with Complement, have also been shown to be capable of ADE 71,72

Given the significant stiffness of the TME, anti-fibrosis emerges as a promising therapeutic approach for augmenting immunotherapy by targeting remodeled ECM components

Nordmann AJ, SuterZimmermann K, Bucher HC, et al

Mounjaro was FDA-approved in 2022 for type 2 diabetes, while Zepbound received FDA approval in November 2023 for chronic weight management

NeuroReport 29(11):945953

Recent imaging studies reveal that BBB breakdown and glymphatic system impairment associated with gliosis occur early in aging, particularly in the hippocampus, and are exacerbated in mild cognitive impairment, correlating with pericyte injury (Montagne et al., 2015)
