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When Nrf2 responses are inadequate, lipid peroxides can trigger inflammation through the nuclear factor kappa B (NF-B) pathway ( NF-B functions as a principal modulator of inflammatory processes (Nowak and Relja, 2020)
Medically, this condition is known as melasma
They are also at higher risk of developing pernicious anaemia, a condition where antibodies are produces against the carrier of vitamin B12 in the gut, intrinsic factor
A 2014 meta-analysis (pooled analysis of published data) showed fumaric acid treatment was as effective as methotrexate for the treatment of psoriasis (Schmitt 2014)
2016;11(5):e0155070
The abnormal processing of sensory inputs in the CNS [68]
