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It was found that the anti-atherosclerotic effect of berberine was associated with the stimulation of Akkermansia in ApoE -/- mice ( Fecal microbiota transplantation (FMT) is a promising method of introducing healthy bacteria from healthy subjects into the gastrointestinal tract of patients with dysfunctional guts, which has received much attention in recent years ( Although gut microbiota-targeted therapy to treat CVD is promising in the context of increasing positive experimental and clinical evidence, discrepant results have also been reported in both experimental and clinical studies

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A recent study suggested that plasma levels of 5-MT, a compound related to serotonin metabolism, may be decreased in CFS patients, but this has been interpreted as a confounder caused by serotonin-selective reuptake inhibitor (SSRI) use in these patients ( The principal role of carnitine is to transport long-chain fatty acids into the mitochondria for energy production via beta-oxidation ( While carnitine supplementation could have benefits, some recent studies suggest that chronic oral L-carnitine administration may be associated with an increased risk for atherosclerosis via increased trimethylamine (TMA) and/or trimethylamine N-Oxide (TMAO) levels ( Mitochondrial dysfunction has been suggested to contribute to CFS ( The mechanisms that link carnitine intake, S-5-HT, and fatigue, in both CFS and hypothyroidism, are yet unknown

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For those specifically seeking peptides for energy , Lipo-C provides a different mechanism than stimulating peptides, working at the metabolic level rather than through neurotransmitter modulation

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Ethics statement The studies involving humans were approved by the Ethical Committee of the Medical University of Vienna (EK Nr: 2105/2021) and Ethical Committee of the University of Vienna (Reference number: 00871)

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This definition is generous as it applies equally to supplements, prescription medication, and some recreational drugs

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