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Tayyeb JZ, Popeijus HE, Mensink RP, Plat J

Curcumin treatment reduces motor impairments and protects against rotenone-induced neurodegeneration in a rat model of Parkinson disease

-Opioid receptor downregulation contributes to opioid tolerance in vivo

Several strategies can be employed to enhance ASTs bioavailability (see Table 7), including novel delivery systems, such as lipid-based carriers, nano delivery with a sustained-release (SR) system, and targeted delivery systems, and structural modifications, such as esterification, isomer form selection, etc