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Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Lebers hereditary optic neuropathy mutation

F.LiuY.BustoR.LeyJ

Generally, GI overproduction of reactive species with oxidative potential can be attributed to both exogenous factors (e.g., smoking, diet, alcohol, and drugs) and endogenous factors (e.g., cellular respiration, respiratory burst, xanthine oxidase, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, cyclooxygenase (COX), transition metals, nitric oxide synthase (NOS), and myeloperoxidase (MPO), which can collectively lead to pathological conditions 88

doi: 10.1371/journal.pntd.0004732 404 ThangamaniS.MohammadH.AbushahbaM

Bibcode:2007Natur.450..383R

The combination of SHD and TAM exhibited additive effects on MCF-7 cell growth inhibition and apoptosis induction (Xu et al., 2016)