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For many people, mitral valve prolapse (MVP) is discovered during a routine exam

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[PubMed] [Google Scholar] 43.Koozehchian MS, Daneshfar A, Fallah E, Agha-Alinejad H, Samadi M, Kaviani M, Kaveh BM, Jung YP, Sablouei MH, Moradi N, et al

The activation of GRB2 results in signal transduction via the activation of the guanine nucleotide exchange factor, SOS (son of sevenless encoded by the SOS1 gene) which in turn activates the monomeric G-protein, RAS

The apex is the axillary inlet, located between the 1st rib, superior border of the scapula, and clavicle