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This microenvironment is characterized by the physiologic presence of bacterial constituents such as endotoxin and by the local release of immunosuppressive mediators such as interleukin-10, prostaglandin E 2 , and transforming growth factor-

Dean et al., 1985)

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A pilot study found that systolegated taVNS tends to prolong RR intervals when stimulated after the R peak and shorten them before, whereas for diastolegated taVNS, later stimulation onset within diastole tends to result in longer subsequent RR intervals

GPCR signaling and cardiac function

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