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In HUA and its ensuing complications, MSU crystals also escalate their role in prompting macrophages to produce inflammatory factors by mediating other cytokines such as leptin (45)

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doi:10.1093/ajcn/80.3.539 Lee JE, Jacques PF, Dougherty L, et al

M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling