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Importantly, clinicians must exclude mechanical obstruction and other organic pathology before attributing symptoms to gastroparesis

my hunger cues and cravings often pulled me in a different direction, no matter how strong my intentions were

Immunology (2010) 129:15469

Interaction risk

However, with significant weight loss comes an increased need for nutritional guidance to help patients maintain quality of life and avoid nutritional deficiencies commonly observed during caloric restriction

However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])