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Finally, they tested the LOXL-2/3 inhibitor in rats with lung fibrosis and found that although there was no effect on total collagen content in the lungs, the treated rats had reduced fibrosis and improved lung function, with no adverse effects

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There are mechanisms that also promote extrusion of Ca 2+ from the intracellular space to the extracellular space via membrane pumps such as the plasma membrane Ca 2+ -ATPase (PMCA), and the Na + /Ca 2+ exchanger which is activated by elevated levels of Ca 2+ and is dependent on the Na + gradient, regulated by the membrane Na + /K + ATPase

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