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While it doesnt contain retinoids, it pairs well with retinoid regimens by targeting puffiness through melatonin, caffeine, and antioxidant support, says Pooja Rambhia, MD, a board-certified dermatologist based in New York City

2009 May;79(3):131-41

Endocrinol Diabetes Metab Case Rep 2021:210070

[Google Scholar] 149.Yeates KO, Swift E, Taylor HG, Wade SL, Drotar D, Stancin T, Minich N

That way you keep the benefits of intentional supplementation without trading safety for convenience
