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Metformin Metformin, an antihyperglycemic agent used as first-line treatment for prediabetes and diabetes, might reduce the absorption of vitamin B12 and significantly reduce serum vitamin B12 concentrations

O.GlotfeltyE

doi: 10.3389/fnut.2024.1381125 305 MehmoodSAbbasiAMHussainHKhanSAAlmutairiHHIsmailAMet al

Wei W et al

Steinberg et al

In addition, it stimulates the activity of some enzymes of the glycolytic pathway and lactate dehydrogenase, promoting the conversion of pyruvate to lactate and limiting oxidative phosphorylation (FOx)
