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Most data are derived from animal and cell culture experiments

TDP-43-induced inflammatory responses in microglia were attenuated when treated with an IL-6 trans-signaling inhibitor in vitro , suggesting that IL-6 trans-signaling may act as a potential driver of inflammation in ALS pathogenesis (Risby-Jones et al., 2025)

Compounds such as lycopene [137], fisetin [138], -carotene [139], and sulforaphane (SFN) protect mitochondria and activate cytoprotective antioxidant pathways [97]

There was no significant difference in vasorelaxation induced by 0.1 or 1 g/ml BPC 157 in aorta without endothelium

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