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The fat cells start being targeted by the cold

High-Density Lipoproteins: Biology, Epidemiology, and Clinical Management
Morse, D
Indeed, OCTN1 exerts its effect by facilitating the uptake of several anticancer agents, such as camptothecin, cytarabine, daunorubicin, and mitoxantrone [26, 47]

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A.YoshidaN.et al