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Thiazolidinediones therefore promote increased FA uptake and storage in subcutaneous adipose tissue, reducing levels of circulating FA and triglycerides.79 Thiazolidinediones have also been shown to stimulate specific proteins involved in glucose metabolism, including pyruvate dehydrogenase.2 Overall, by reducing FA delivery to the heart and increasing flux through glycolysis, thiazolidinediones may help to rebalance the metabolic alterations in the diabetic heart

Even natural supplements can potentially interact with each other, so clearly share all of the medications and supplements you are currently taking with your physician

It also means understanding that your body's needs change