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In PD, folate deficiency and hyperhomocysteinemia worsen motor deficits and nigral dopaminergic loss, with mechanistic links to glutathione depletion, mitochondrial dysfunction, oxidative stress and NLRP3-mediated inflammation [82, 171]

Metabolites 2021, 11 (9), 613

Since the first reported target gene of HIF-1 (erythropoietin), hundreds of downstream targets have been identified, demonstrating the complexity and importance of the HIF-1 signaling pathway (15)

MllerJBertschTVolkeJSchmidAKlingbeilRMetodievYet alNarrative review of metabolomics in cardiovascular disease

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