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To determine the liver protection by rectal ozone insufflation in patients with RA, a controlled clinical trial with 100 patients was performed: n = 50 as MTX-group (MTX + Ibuprophen + folic acid) and n = 50 as ozone group receiving the same medication + rectal ozone insufflations as described above and in detail in [26,27,28]

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dihydropterins and tetrahydropterins, Pterin dihydroform may participate in the synthesis of folate while tetrahydro form acts as pterin cofactor

4C and Supplementary Figure S3)