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The lack of osteogenic response is not due to a reduced osteocyte density (64), suggesting that osteocyte-derived IGF-I not only mediates bone osteoblast/osteocyte differentiation, but also the mechanosensitivity of the cells (Figure 2)

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In addition, we determined structures of CydDC in the presence of a combination of heme and thiols (GSH, glutathione disulfide (GSSG), l-Cys) to assess whether these molecules may be heme-dependent cosubstrates