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bioRxiv2025 Jan 10

The highly reactive nature of the active site cysteine, in a relatively exposed surface position, represents the major challenge because a reversible effective inhibitor should out-compete the high cellular concentration of glutathione

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Mirone C, Preziosi D, Mascheri A, Micarelli G, Farioli L, Balossi LG, Scibilia J, Schroeder J, Losappio LM, Aversano MG, Stafylaraki C, Nichelatti M, Pastorello EA (2015) Identification of risk factors of severe hypersensitivity reactions in general anaesthesia

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