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Although chronic stress and high levels of circulating stress hormones are a clear risk factor for depression ( The Effect of Antidepressants on Mitochondria There has been quite a bit of work done to try to understand the effect of antidepressant drugs on mitochondrial function

10.1186/1746-1596-8-123 Diagn

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Chloramphenicol may impair the haematological response to B12 therapy

Our data provides evidence for a complex functional interaction between LRRK2 and ArfGAP1 that serves to regulate ArfGAP1 subcellular localization, protein interactions, activity and neuronal toxicity via LRRK2-mediated phosphorylation of its membrane-binding ALPS2 motif