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Meldonium, known for its anti-atherosclerotic and anti-ischemic properties, is an analogue of carnitine that lowers the generation of TMA from L-carnitine, but not choline, and improves endothelial function [22,127,140]

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Ascorbic acid is the most commonly used form of Vit C in skincare, but other forms such as ascorbyl palmitate and sodium ascorbyl phosphate are also utilized

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In this review, we discuss the most relevant aspects of the BBB penetration mechanisms, observing both invasive and non-invasive methods of drug delivery