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BTK inhibition has been shown in preclinical trials to reduce major pathogenic aspects of MS such as B cell activation, CNS lymphocyte infiltration, pro-inflammatory microglial activation and demyelination
doi:10.1016/S0962-8924(00)01834-1
doi: 10.1016/j.clineuro.2025.108725
In contrast, the severity of neuropathic symptoms remained constant in the placebo group over the dosing period, whereas it significantly improved in the ARA 290 group (Figure 4B)
[DOI] [PubMed] [Google Scholar] 20.Pihan G., Majzoubi D., Haudenschild C., Trier J.S., Szabo S
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