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It was observed that Nestin-Cre-mediated combined deletion of Hdac1 and Hdac2 leads to severely impaired brain development and embryonic lethality in agreement with a previous study 81 using GFAP-Cre transgene

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Programmed death-ligand 1 (PD-L1), encoded by the CD274 gene and belonging to the B7 family of immune checkpoint proteins, is frequently overexpressed in the tumor microenvironment, facilitating immune evasion

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10.1038/ni1142