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Nat Genet 39: 106870, 2007
# combined score (08)semiquantitative neuropathological scoring system
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Transcriptional profiling reveals that both the mito-nuclear retrograde (MNR) and the Pap1-dependent oxidative stress response pathways are induced in these mutants, resulting in the upregulation of genes encoding antioxidants, membrane transporters, and thereby increased efflux
Svoronos, Paris
Thus, macrophage polarization in diabetes and its complications is regulated through multidimensional mechanisms and targeting polarization states along with metabolic reprogramming offers promising therapeutic strategies
