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These reactions introduce or unmask functional groups (e.g., hydroxyl, carboxyl, amino) on the molecule, often resulting in the formation of intermediate metabolites

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References Alvarez-Fernandez, M

Humana Press Inc, 19-33, 2005

The main enzyme in the glycine cleavage pathway, GLDC, is upregulated in lung-tumor initiating cells as well as glioblastomas, and sustained GLDC hyperactivity has been shown to be critical for tumorigenesis (Zhang et al., 2012)