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Repositories of serum and tissue samples from in vivo studies would also be helpful in laying the groundwork for pre-clinical or translational studies

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Regulation of phase II biotransformation enzymes by steroid hormones

In vivo data on colonic mucus in newborn humans, pigs and mice show a predominance of acidic mucins over neutral mucins at birth ( Muc-3/2/ 5 mRNA expression levels progressively increase from 5 to 15 days and at 6 weeks of age (78)

PMC 3920715

Activation of mTOR in senescent cells contributes to cellular dysfunction and the pro-inflammatory SASP.134 Inhibition of mTOR has been shown to reduce the expression of SASP factors and improve tissue function in animal models of aging.135 Modulation of the SASP: Senescent cells secrete a variety of pro-inflammatory cytokines, chemokines, growth factors, and proteases collectively known as the SASP