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Cooney LG, Lee I, Sammel MD, Dokras A

Matching with these findings, bulk transcriptomic profiling of cerebellar tissues harvested from 6-month-old mice revealed that differentially downregulated genes were highly involved in glycolysis, adipogenesis (i.e., lipid anabolism), and myogenesis (i.e., protein anabolism) (Supplementary Fig

We also demonstrated that NRF2 was upregulated in MT3 knockdown, with elevated Zn 2+ in preosteoclasts, and inhibition of intracellular Zn 2+ by TPEN decreased NRF2 expression

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