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Independent verification at every stage

Adequate B-12 in the diet is necessary to keep down levels of homocysteine in the blood

Among patients pretreated with one prior ROS1 TKI and no prior chemotherapy, the ORR was 38%

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If B12 blood levels and MMA are both high, a functional B12 deficiency could be preventing B12 being useful at cell/tissue level

For patients whose levels fall in the borderline or gray zone, a methylmalonic acid (MMA) test provides greater specificity MMA levels rise when B12 is functionally inadequate at the cellular level, even if serum B12 appears borderline normal