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Sometimes abbreviated as AEDG after the single-letter codes for these amino acids, this sequence creates a remarkably small peptide with a molecular weight of approximately 390 daltons

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The next studies revealed particular relationships with sphincter function [197], free-radical-induced injuries [197], bleeding [144,187,192], non-specific and specific NSAID-induced lesions [201], general anesthesia (thiopental) [202] and local anesthesia (lidocaine) [203] induced disturbances, and rat models that resemble schizophrenia-positive symptoms and negative symptoms [171,200]

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