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The key efflux pumps present in the BBB comprise P-glycoprotein (P-gp), the breast cancer resistance protein, and various drug resistance-associated proteins[37]

The combination of hesperidin (100 mg/kg) with CoQ 10 (40 mg/kg) and hesperidin (100 mg/kg) with CoQ 10 (40 mg/kg) and olanzapine (5 mg/kg) did not any produce a significant protective effect on immobility period as compared to their per se effect in ketamine-treated animals