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Adv Mater, 2020, 32: 1902333 Ding Z, Gu Y, Zheng C, et al

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PPAR activator has been previously reported to protect against acetaminophen-induced hepatotoxicity, but fenofibrate, a lipid-lowering drug that activates PPAR, has a common side-effect causing liver injury

A group of neurons in the hypothalamus produces and releases gonadotropin-releasing hormone (GnRH), a decapeptide, into the hypothalamic-hypophyseal portal system, which stimulates the anterior pituitarys gonadotrophs to release LH and FSH into the bloodstream