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10.1093/alcalc/agq034 57 LiuJ.WangX.LiuR.LiuY.ZhangT.FuH.et al (2014)

and S.H.A.E

However, in recent years it has also been unequivocally demonstrated that not only effective reduction of cholesterol concentration according to the rule of the lower the better is important, but that achievement of the therapeutic goal for LDL-C as soon as possible, according to the rule of the earlier the better, and maintaining it as long as possible (= the longer the better), is also of critical importance [2, 6, 7, 106]

Therefore, some have criticized the results published by Podmore et al

But the doctor who performed the surgery told the inquest he was not aware of any specific risks of the method he was using

High doses are more likely to produce side effects